Quick Guide
Aftercare Following Your Polynucleotide or Skin Booster Treatment
Thank you for attending for your treatment today.
The following guidance applies to both polynucleotide treatments and skin booster treatments.
What to Expect
It is normal to experience some temporary effects following treatment, including:
- Small bumps or raised areas at the injection sites
- Mild redness, swelling or tenderness
- Minor bruising
- Mild itching or a feeling of tightness
These effects usually settle within 24 to 72 hours, although bruising may occasionally last longer.
Please note that one side of the face may heal more quickly than the other. Final assessment of your results is best performed at your review appointment.
During the First 24 Hours
Please avoid:
- Touching, pressing, rubbing or massaging the treated area unnecessarily
- Applying make-up for at least 12 hours (ideally until the following day)
- Strenuous exercise
- Alcohol consumption
- Sleeping directly on the treated area where possible
- If required, a cool compress may be applied gently to reduce swelling.
During the First 48 to 72 Hours
Please avoid excessive heat exposure, including:
- Saunas
- Steam rooms
- Hot baths
- Sunbeds
- Prolonged or excessive sun exposure
Use a high-factor sunscreen (SPF 50+) if outdoors.
During the First 5 to 7 Days
- Avoid active skincare products that may irritate the skin, including:
- Retinol and retinoid products
- Vitamin A preparations
- AHAs and BHAs
- Exfoliating acids or scrubs
- Strong Vitamin C products if they cause irritation
Also avoid:
- Facial massage
- Gua sha or facial sculpting tools
- Swimming pools and hot tubs where possible
- If you are prone to cold sores (herpes simplex infections), please be aware that facial injections may occasionally trigger a recurrence.
During the First 1 to 2 Weeks
Avoid the following treatments until the skin has fully settled:
- Chemical peels
- Microneedling
- Laser treatmets
- IPL treatments
- Radiofrequency treatments
- Microdermabrasion
- Facial waxing
- Other facial aesthetic procedures unless advised otherwise
Medications and Supplements
Please continue all medications prescribed by your GP, hospital specialist or consultant unless otherwise advised.
Where possible, avoid supplements and medications that may increase bruising for several days after treatment, including:
- Aspirin (unless medically prescribed)
- Ibuprofen or anti-inflammatory medication (unless medically prescribed)
- Gingko biloba
- Garlic supplements
- Flaxseed oil
- Cod liver oil
- Vitamin A supplements
- Vitamin E supplements
- Other essential fatty acid supplements
If you are prescribed any medication, please do not stop it without medical advice.
Ongoing Skin Care
To optimise your results:
- Use a gentle cleanser and moisturiser
- Keep your skin well hydrated
- Apply SPF 50+ daily
Follow your usual gentle skincare routine once any redness or sensitivity has settled
Results from polynucleotide treatments develop gradually over the following weeks as collagen and tissue repair processes are stimulated.
When to Contact the Cademuir Clinic Urgently
Please seek advice immediately if you experience any of the following:
- Severe pain or pain that is worsening
- Significant or increasing swelling
- Increasing redness after 48 hours
- Skin becoming hot, inflamed or increasingly tender
- Pus, discharge or other signs of infection
- Skin blanching (areas of whitening)
- Dark, mottled or discoloured patches on the skin
- Blistering or pustules
- Increasing itchiness associated with swelling or redness
- Any visual disturbance or pain around the eye area
If you are concerned about any aspect of your recovery, please contact the clinic for advice.
Follow-Up
Polynucleotide and skin boosters treatments are usually performed as a course of three treatments, typically 2 to 4 weeks apart. Maintenance treatments are often recommended every 4 to 6 months, depending on your skin quality, treatment goals and clinician recommendations.
We look forward to seeing you at your review appointment. If you have any concerns before then, please do not hesitate to get in touch.

